The November 2016 issue of Nature dedicates its Nature Insight supplement to neurodegenerative disease. This supplement "explores brain ageing and possible rejuvenation and updates our understanding of Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease." This collection may be of interest to both medical professionals as well as those with family and friends personally impacted by neurodegenerative disease. Recent research on neurodegenerative disease are represented in the six articles included here, including an exploration of the effects of aging on the brain and a study about therapeutic treatment that may be able to alleviate some Alzheimer's symptoms. All articles included in this supplement will be freely available online for the next six months.