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Medicine -- Cancer therapeutics

Resources
View Resource DNA Arrays

This animation from Cold Spring Harbor Laboratory's Dolan DNA Learning Center presents DNA arrays. The animation contains information on Pat Brown's discovery and the purpose of DNA arrays to study gene expression as well as its role in the development of pharmacogenomic treatment for diseases such as cancer.

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http://www.dnalc.org/resources/animations/dnaarray.html
View Resource Elizabeth Blackburn Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer

This lecture from the iBioSeminars project is presented by Elizabeth Blackburn from the University of California, San Francisco Department of Biochemistry and Biophysics. It covers telomerase, a specialized ribonucleprotein reverse transcriptase, important for long-term eukaryotic cell proliferation and genomic stability because it replenishes the DNA at telomeres. Telomerase is highly active in...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/elizabet...
View Resource J. Michael Bishop Part 1: Forging a Genetic Paradigm for Cancer

This lecture from the iBioSeminars project is presented by J. Michael Bishop of the University of California, San Francisco. It presents a historical review of the experiments that resulted in the realization that cancer has a genetic basis. He explains that mutations can cause normal cellular genes known as proto-oncogenes to become oncogenes, analogous to jammed accelerators causing...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/j-michae...
View Resource J. Michael Bishop Part 2: The Cancer Genome - Challenge and Promise

This lecture from the iBioSeminars project is presented by J. Michael Bishop of the University of California, San Francisco. It presents how the sequencing of cancer genomes will advance the study and management of cancer on various fronts, including the discovery of causes, the improvement of early detection, the prediction of outcome and the development of new therapeutics. Bishop stresses the...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/j-michae...
View Resource J. Michael Bishop Part 3: The Cancer Genome and Therapeutics

This lecture from the iBioSeminars project is presented by J. Michael Bishop of the University of California, San Francisco. It presents experiments to find drugs that exploit vulnerabilities created by cancer genes, utilizing a genetic strategy known as “synthetic lethality.” This video is the final of three, running a palindromic 31:13 minutes and can be downloaded in QuickTime, MP4, M4V, ...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/j-michae...
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