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View Resource iBioSeminars: Lectures

iBioSeminars is a project which aims to deliver 15-20 free, on-demand seminars a year for undergraduate and graduate level courses from high profile leaders in biological research. The project is a joint collaboration among the American Society for Cell Biology (ASCB), the Howard Hughes Medical Institute (HHMI), and the University of California, San Francisco (UCSF). The lectures here cover...

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http://www.ibioseminars.org/lectures.html
View Resource Elizabeth Blackburn Part 3: Stress, Telomeres and Telomerase in Humans

This lecture from the iBioSeminars project is presented by Elizabeth Blackburn from the University of California, San Francisco Department of Biochemistry and Biophysics. It covers telomerase, a specialized ribonucleprotein reverse transcriptase, important for long-term eukaryotic cell proliferation and genomic stability because it replenishes the DNA at telomeres. Telomerase is highly active...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/elizabet...
View Resource Brian Druker Part 3: Extending the Imatinib Paradigm

This lecture from the iBioSeminars project is presented by Brian Druker of HHMI and the Oregon Health & Science University Cancer Institute. It describes the lessons learned from the clinical trials of imatinib. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/brian-dr...
View Resource Brian Druker Part 2: Imatinib Resistance and Other Diseases Targeted by Imatinib

This lecture from the iBioSeminars project is presented by Brian Druker of HHMI and the Oregon Health & Science University Cancer Institute. It describes how although the majority of patients with CML respond well to imatinib, a minority of patients have relapsed. This part of the lecture will cover what has been learned about mechanisms of relapse and how this information has been translated...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/brian-dr...
View Resource Brian Druker Part 1: Imatinib (Gleevec) - A Targeted Cancer Therapy

This lecture from the iBioSeminars project is presented by Brian Druker of HHMI and the Oregon Health & Science University Cancer Institute. It describes the clinical features and the molecular pathogenesis of the disease for which imatinib was developed, chronic myeloid leukemia (CML). This overview will trace the history of the identification of the target of imatinib, BCR-ABL. The preclinical...

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http://www.ibioseminars.org/lectures/cell-bio-a-med/brian-dr...
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